International calls: TB jab 'successful' in HIV-positive patients
Tuesday, Feb 02, 2010 Filed Under :Planet Talk Instant News
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A new vaccine against tuberculosis (TB) for people who already have HIV infection has shown promising effects in clinical trials, it is reported.
The vaccine, which is known as Mycobacterium vaccae (MV), reduced the rate of definite TB by 39 per cent among 2,000 HIV-infected patients in Tanzania, according to data published in the online issue of the journal Aids.
Scientists at Dartmouth Medical School (DMS) reported the results, with Professor von Reyn at DMS referring to the trial as a "significant milestone", as it is the first to demonstrate that any type of vaccine can prevent an infectious complication of HIV in adults.
Meanwhile, a separate study published in the journal Nature is said to have made a breakthrough in HIV research that had eluded scientists for over 20 years.
Researchers from Imperial College London and Harvard University have grown a crystal that reveals the structure of an enzyme called integrase, which is found in retroviruses like HIV.
This development could mean that researchers can begin to fully understand how existing drugs that inhibit integrase are working and how they might be improved.
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